Efficacy of Lagopsis supina to promote blood circulation, remove blood stasis, and block inflammation in a rat model of traumatic blood stasis

Lagopsis supina (Steph) IK. Gal. was a traditional Chinese medicinal plant for promoting blood circulation and removing stasis (PBCRBS), anti-inflammatory diuresis with little scientific validation. The aims of this study were first to evaluate the PBCRBS effects L. in rat model traumatic (TBS). We demonstrated that an ethanolic extract (LS, 460 mg/kg/d) possessed significant remarkable inhibitory effect on inflammation cytokines, which associated renovated amount injured muscle fibers, alleviate degree damaged tissue edema, decreased number inflammatory cells, increased capillary hyperplasia by hematoxylin eosin (HE), as well remarkably down-regulated ( p < 0.05 or 0.01) levels including TNF-α, IL-6, IL-8, IL-10 ELISA. This finding provide pharmacological basis partial interpretation clinical application supina, has therapeutic properties syndrome (BSS) inflammation-related diseases.